Abstract
Objectives: To investigate the correlation between serum uncoupling protein 2 (UCP2)level and severity of coronary artery disease (including Gensini score and criminal vessel counts)in patients with stable coronary artery disease (SCAD),and analyze the predictive value of serum UCP2 and urine acid (UA) on SCAD. Methods: 330 patients in Department of Cardiology,the First Affiliated Hospital of Chengdu Medical College from June 2015 to June 2017 were included.240 patients with SCAD (SCAD group),90 patients without coronary artery disease (control group) were diagnosed. Serum UCP2 level was detected by enzyme linked immunosorbent assay (ELISA)sandwich method and analyzed statistically. Results: Baseline characteristics were similar between the two groups. Serum UCP2 and UA level of SCAD group was higher than the control group:UCP2[1.60 (0.67,4.60)μg/L]vs.[0.42 (0.28,0.59)μg/L](p < 0.01),UA[(365.74 ± 66.06)μmol/L]vs.[(268.11 ± 45.81)μmol/L](p < 0.01). Multivariate Logistic regression analysis showed that UCP2 (OR = 1.010,95%CI:1.001–1.020, P = 0.025) and UA (OR = 1.039,95%CI:1.007–1.072,P < 0.05) were independently associated with SCAD. Correlation analysis showed that serum UCP2 level was positively correlated with Gensini score (r = 0.780,P < 0.01) and criminal vessel counts (r = 0.543,P < 0.01). The receiver operating characteristic curve (ROC) showed that the optimal cutoff point of serum UCP2 level predicting SCAD was 0.64 μg/L. The sensitivity was 0.833 and the specificity was 0.944. The difference in area under the curve between serum UCP2 and UA (ΔAUC) was not statistically significant (P > 0.05). Conclusion: The higher serum UCP2 level in patients with SCAD,the more severe coronary lesions. Serum UCP2 level may be a new indicator of predicting SCAD,which was no significant difference compared with traditional oxidative stress indicator of serum UA.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
