A8550 Correlation between Pulmonary Hypertension and Left Ventricular Mass Index and Diastolic Dysfunction in Systemic Lupus Erythematosus Patients

Abstract

Objectives: To determine the prevalence of echocardiographic feature of systemic lupus erythematosus patients and investigate the relationship of the left ventricular mass index (LVMI) and left ventricular (LV) diastolic dysfunction against PH in SLE patients. Methods: A total sampling of 256 SLE cases were identified from 2011–2018 in West Java, Indonesia. From 256 cases, 161 patients were performed transthoracic echocardiography (TTE) for further analysis. The data then were analyzed using SPSS version 20.0. Results: The mean age of subjects was 31.22 (± 12.123) years, the male to female ratio was 2.5:97.5. The prevalence of PH in SLE was 35.40 %. The average value of mean pulmonary arterial pressure (mPAP) was 22.98 (± 9.893) mmHg, the mean Tricuspid Annular Plane Systolic Excursion (TAPSE) was 19.88 (± 4.166) mm, the mean LV mass was 192.34 (± 78.106) gram, the mean LVMI was 131.58 (± 53.149) gram/m2, the left ventricle ejection fraction (LVEF) was 58.71 (± 13.885) %, the mean E/A was 1.31 (± 0.526), and the mean deceleration time (DT) was 173.36 (± 47.503) ms. The mPAP showed highly significant correlation with TAPSE (p < 0.001), significant correlation with LVMI (p < 0.05), highly significant correlation with LVEF (p < 0.001), and highly significant correlation with DT (p < 0.001). Conclusion: We found a significant correlation between pulmonary hypertension againts left ventricular mass index and left ventricular diastolic dysfunction in systemic lupus erythematosus patient.