A-77 Nonverbal Memory Dysfunction and Migraine-Related Disability Predict Subjective Cognitive Symptoms in Adults with Migraine

Abstract

Abstract Objective This study investigated the relationship between subjective cognitive symptom reporting and objective cognitive functioning in adults with migraine. Method 88 participants (Mdn age = 46.0 [35.25–56.75]; Mdn years of education = 16.0 [13.0–19.0]; 88.6% female) completed neuropsychological testing and questionnaires assessing migraine disability (Migraine Disability Assessment Scale) and subjective cognition (Sickness Impact Profile-Alertness Behavior Subscale). Participants had primary headache disorder diagnosis of migraine. Bivariate correlations and hierarchical linear regression were performed. Results 83% of participants had episodic migraine (< 15 headache days/month) and 58% reported low or moderate disability (MIDAS ≤21). Subjective cognitive dysfunction was associated with lower education (ρ = −0.254; p = 0.018), higher disability (t(84) = −3.00, p = 0.004); and lower scores on coding (r = −0.224, p = 0.023) TMT-A (r = −0.238, p = 0.029), RCFT- Immediate Recall (r = −0.028, p = 0.010), RCFT- Delayed Recall (r = −0.38, p < 0.001), RCFT-recognition (r = −0.40, p < 0.001), and animal fluency (r = −0.27, p = 0.013). Migraine-related disability and RCFT- Delayed Recall (ß = −0.368, SE = 0.006).) accounted for 45.9% of variance in subjective cognitive symptom reporting. The addition of RCFT-recognition (ß = −0.050, SE = 0.025) increased explanation of variance by 4.1%. Conclusion Nonverbal memory dysfunction and higher disability may predict subjective cognitive complaints. This study contributes to the limited knowledge of objective and subjective cognitive functioning in adults with migraine.