A7546 To study autonomic variability in offsprings of hypertensive parents in lucknow using handgrip dynamometer and galvanic skin response

Abstract

Objectives: Positive family history of hypertension is one of the risk factors for being hypertensive in future life for children. Young adults with hypertensive first degree relatives constitute a special risk group that should be closely monitored. Early detection of proneness to hypertension may help an individual to lead a healthy life by altering his/her lifestyle. The aim of the present study is to investigate the autonomic variability in offspring of hypertensive parents. Methods: This is a case control study. In this study 60 healthy young subjects, (n = 60; 30 cases, 30 controls, age: 18–25 years both male and female) were chosen. The blood pressure of the participants was recorded using a electronic blood pressure instrument (Cannon). The participant was asked to sustain isometric handgrip at one third of Maximum voluntary contraction(MVC). At the completion of one minute, blood pressure was measured. Three minutes after the handgrip test, the blood pressure was noted again (recovery). GSR was recorded using Medicaid Polyrite machine. Results: In cases the diastolic blood pressure after 3 minutes of withdrawal of stressor was seen to be significantly higher (p value < 0.05) than baseline diastolic blood pressure. GSR recording was found to be significantly lower in cases than in controls (p value < 0.05). The change in skin potential is in response to stress which alters sympathetic activity. Conclusion: Once stimulated by a stressor, sympathetic system causes rise in blood pressure. The persons who show higher cardiovascular reactivity to a stressor but slower rate of recovery after the withdrawal of the stressor indicate that their autonomic control system is weak. Decreased GSR recordings also demonstrate altered sympathetic activity.