A6768 The association and comparative assessment of cutoffs for the cardio-ankle vascular index and brachial-ankle pulse wave velocity –the Coupling Registry-

Abstract

Objectives: Pulse wave velocity (PWV) and cardio-ankle vascular index (CAVI) are measurements of arterial stiffness, and are widely used as indices of arteriosclerosis. In Japan, brachial-ankle PWV (baPWV) is generally used to measure PWV, and while the reference value for this parameter is specified in Japanese guidelines, the CAVI value has not been standardized. The aim of this study was to investigate the association between CAVI and baPWV, and evaluate the reference value of CAVI which was corresponded to a baPWV cutoff value. Methods: We measured CAVI in 4,545 patients with at least one cardiovascular risk factor, and baPWV in 1,737 of these patients. Results: The association between CAVI and baPWV was positive and significant (r = 0.50, p < 0.001). The CAVI corresponding to baPWV 14m/s derived from the regression line was 8.303 and the CAVI corresponding to baPWV 18m/s was 9.059. The proportion of low risk (CAVI < 8.303) was 35.0%, that of medium risk (CAVI 8.303–9.058) was 23.0%, and that of high risk (CAVI ≥ 9.059) was 42.0%, respectively. The percentages of patients with baPWV < 14m/s, baPWV 14–18m/s and baPWV ≥ 18m/s were 22.9%, 47.3% and 29.8%, respectively. The average baPWV in low-risk patients (CAVI < 8.303, n = 642) was 14.97 ± 2.91m/s, that in medium-risk patients (CAVI 8.303–9.058, n = 408) was 16.12 ± 2.80m/s, and that in high-risk patients (CAVI ≥ 9.059, n = 687) was 18.40 ± 3.51m/s. Conclusion: CAVI < 8.303 corresponded to a baPWV cutoff of 14m/s, and CAVI ≥ 9.059 corresponded to a baPWV cutoff of 18m/s.