Abstract
Decreasing myocardial temperature during ischemia is a powerful cardioprotective strategy, but application in the setting of acute myocardial infarction has been impaired by the lack of a practical methodology to quickly cool the heart. We investigated whether total liquid ventilation with a temperature-controlled mixture of perfluorocarbons could elicit rapid cardioprotective cooling in a rabbit model of myocardial infarction. We performed a 30-min coronary artery occlusion followed by 3 h of reperfusion in pentobarbital-anesthetized open-chest rabbits.
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