A5940 The relationship between intermedin and early damage of kidney caused by hypertension

Abstract

Objectives: This study aims to observe the association between early target organ damage caused by hypertension and intermedin. To study the value of IMD in subclinical target organ damage caused by hypertension. Methods: 50 simple hypertension patients, 41 hypertensive patients with microalbuminuria and 40 healthy controls were enrolled in our study. We collected morning urine to check urinary albumin-creatinine ratio (UACR) in clinical laboratory of our hospital and urine neutrophil gelatinase-associated lipocalin (UNGAL) by method of enzyme-linked immunosorbent assay (ELISA). Results: Plasma IMD of Healthy control group is 97.25 ± 4.78pg/ml, Plasma IMD of simple hypertension group is 105.50 ± 7.69pg/ml, Plasma IMD in group of hypertension with microalbuminuria is 121.05 ± 6.59pg/ml. UNGAL of Healthy control group is 1.24 ± 0.51ng/ml, UNGAL of simple hypertension group is 3.15 ± 0.27ng/ml, UNGAL in group of hypertension with microalbuminuria: 3.84 ± 0.45ng/ml. Binary logistic regression analysis reveals that SBP (OR = 1.905, P = 0.023, 95% CI: 1.006–118.5), IMD (OR = 2.027, 95% CI:1.151–357), LDL (OR = 2.022, 95%CI:1.073–2.551) and cf-PWV (OR = 1.825, 95% CI:1.577–2.919) are related to the elevation of microalbuminuria. The ROC curve area that IMD forecasts microalbuminuria is 0.949, P < 0.001, 95%CI:0.907–0.991. Binary logistic stepwise regression analysis shows that SBP (OR = 1.159, P = 0.028, 95 %CI:1.016 - 123.2), IMD (OR = 1.425, P = 0.012, 95% CI:1.082 - 1.878) are related to the elevation of UNGAL. Conclusion: UNGAL elevation is earlier than that of microalbuminuria in hypertensive renal damage, that is, the tube and interstitial damage Occur before than glomerular lesion. Plasma intermedin is positively correlated with severity of early subclinical kidney damage cauesd by hypertension, it may be seen as early biomarker.