A5907 Prevalence of hyperuricemia and its correlates in Chinaʼs Sichuan Tibetan area

Abstract

Objectives: The prevalence of hyperuricemia in tibetan area has not been extensively investigated. We aimed to estimate the prevalence and risk factors of hyperuricemia in Sichuan Tibetan. Methods: We totally investigated 910 subjects in this cross-sectional study. 849 subjects accepted serum uric acid test. Hyperuricemia (HUA) was defined as serum uric acid ≥420 μmol/l in men and ≥360 μmol/l in women. Data regarding the demographic and lifestyle characteristics and the blood biochemical indexes of these participants were collected by well-trained personnel. Results: The prevalence of HUA was 48.6% in all participants of this study, 57.2% for male and 43.1% for female (P < 0.001). The prevalence of HUA was 50.7%, 45.4% and 54% for Han, Tibetan an Yi respectively (P = 0.158). The prevalence of HUA was 33.3%, 43.0%, 50.6%, 54.4%, 48% and 43.0% for age 25–35, age 36–45, age 45–55, age 56–65, age 66–75 and age 76–85 respectively. Binary logistic regression analysis showed that current drinking (OR = 1.815, 95%CI: 1.175–2.805, P = 0.007), hip circumference (OR = 1.036, 95%CI: 1.002–1.071, P = 0.037), weight (OR = 1.032, 95%CI: 1.006–1.058, P = 0.016), creatinine (OR = 1.048, 95%CI: 1.031–1.065, P < 0.001) and hypertension (OR = 1.614, 95%CI: 1.010–2.580, P = 0.046)were risk factors of HUA in all subjects of this study when adjusting confounding factors including SBP, DBP, BMI, sex, age, race, LDL-c, TG, education level and lifestyle which including current smoking, activity, drinking buttered tea and eating meat and eggs. Conclusion: Hyperuricemia was common in Jiulong county, especially among men. The prevalence of HUA in this area was more serious than previous data reported by Chinese study. Current drinking, higher hip circumference, higher weight, higher creatinine and hypertension contributed to HUA in this population.