A5813 The MboI 10631A > G REN/T323C of ETa genes in hypertensive patients

Abstract

Objectives: To study of familial character of essential hypertension EH and to evaluate the role of T323C polymorphism of ETa gene/10631A > G polymorphism REN gene Methods: The study included 40 healthy volunteers and 100 patients with I-III grade of EH, all of them were Uzbek males in the mean age of 51.6 ± 7.5 years. Genotype was performed on the Real-Time PCR Results: The distribution of 10631A > G polymorphism of REN gene in 100 hypertensive patients were as follows: 55% of patients with AA-genotype, 37% with AG-genotype and 8% with GG-genotype (p = 0.25, χ2 = 0.25). Control group-43% of patients with AA-genotype and 57% with AG-genotype (χ2 = 6.87, p = 0.03). Allelic analysis showed a significant difference between G and A alleles in BMI and a tendency for higher SBP in G allele carriers (OR 7.44, 95% CI 0.42–132.07). The distribution of T323C polymorphism of ETa gene in 100 hypertensive patients were as follows: 82% of patients with TT-genotype, 16% with TC-genotype and 2% with CC-genotype, (p < 0.001, χ2 = 164.280). The association between level of BP and T323C polymorphism of ETa gene in Uzbek hypertensive patients were not found. The significant trend to high value of left ventricular mass index (LVMI) was found in account with T323C polymorphism of ETa gene. LVMI was following: 140.54 ± 36.85 g/m2 in T-allele carriers versus 113.52 ± 22.48 g/m2 in C-allele carriers (p = 0.002). The intima/media thikness parameter was revealed significant benefits in C-allele carriers: 0.88 ± 0.26 mm versus 1.03 ± 0.23 in T-allele carriers Conclusion: We found that the 10631A > G polymorphism of the REN gene and T323C of ETa gene was associated with EH and cardiovascular markers. To our opinion, our results are only preliminary and further large case-control studies in our and other Central Asia populations are needed to confirm this association