A5707 Determinants and Regression Equations for the Calculation of Z-scores of Left Heart Structures in Healthy Han Chinese Adult

Abstract

Objectives: Congenital and acquired heart disease remains reliant on detailed measurements of cardiac structures using two-dimensional echocardiography. Calculated Z-scores are often used to normalize these measurements in pediatric patients. However, the determinants of left heart structures in adults are rarely reported. We investigated the predictors of left heart (LH) structures in a healthy Chinese Han adult population and established normative data and regression equations for the calculation of Z-scores. Methods: Two-dimensional and M-mode echocardiography were performed in 604 patients ranging from 18 to 80 years old (age of 44.4 ± 13.6 years, 56.4% male and 43.6% female). Six routine left structural measurements (AOD, LAD, LVDd, LVDs, IVSTd, LVPWd) were determined. Data are presented graphically, and regression equations relating cardiac diameter to the most important determinants involved with calculation Z-scores are derived. Results: Body surface area (BSA) was the strongest determinant of left cardiac structures. (AOD r = 0.42 p < 0.001;LAD r = 0.43 p < 0.001;LVDd r = 0.69 p < 0.001;LVDs r = 0.56 p < 0.001;IVSd r = 0.32 p < 0.001;LVPWd r = 0.36 p < 0.001). BSA-specific reference ranges, regression equations, and scatterplots for the calculation of z scores were determined for each index. Conclusion: BSA is the strongest determinant of left heart structures in Chinese Han adults. The availability of BSA-specific normalized data for the calculation of Z-scores may be valuable for better detection of congenital and acquired heart disease.