A5211 The association of the blood pressure level with the cognitive decline after 3 years among community-dwelling older people

Abstract

Objectives: The ideal blood pressure (BP) goal for very old people is still unclear. The purpose of this study is to investigate the association of BP level with cognitive decline after 3 years among 70 and 90 years old community dwelling Japanese. Methods: Participants in age 70 ± 1 years and 90 ± 1 were randomly recruited from general population participated in the survey called SONIC study. We analyzed subjects who participated in both baseline and follow up study 3 years later; 70 ± 1 years (n = 593), 90 ± 1 (n = 68). The BP and the cognitive function (MOCA-J) were examined on site, and the medical histories and medications were interviewed by the medical professionals. We investigated the associations of the cognitive decline after 3 years with the level of baseline SBP (−120, 120–140, 140–160, 160-mmHg). Results: The mean BP at baseline was 140/79 mmHg in 70 s, and 140/72 in 90 s. The proportion of participants with the cognitive decline was 37.9% in 70 s, and 41.2% in 90 s. There was no significant difference between the baseline BP level and the proportion of participants with cognitive decline 3 years later. There was no correlation between baseline cognitive function and the level of decline. In the baseline cross sectional analysis, we found the association of the lower SBP with the lower cognitive function in 90 s. In the participants whose cognitive function declined after 3 years, we found the significant association of the higher baseline SBP with the greater decline of the cognitive function in 90 s. However, these association was not found in 70 s. Conclusion: In the very old population with the declined cognitive function after 3 years, the higher baseline SBP was associated with the greater decline. Further study is needed to clarify the ideal BP control level for very old people for keeping cognitive function.