A5208Diabetes mellitus after roux-en-y gastric bypass : what happens after weight regain?

Abstract

studies and cases with average follow-up time of at least one year (n1⁄486), pooled mean SD of prevs. post-operative HbA1C was 8.49 1.31 vs. 7.89 1.07 %, respectively (P o0.001, for both analyses using estimated covariance and conservative approach). Improvement in lipid profile and blood pressure was shown in 4 case series. In addition to common postoperative complications of bariatric surgery, profound glycemic changes (diabetic ketoacidosis, and episode of severe hypoglycemia) and GI dysmotility symptoms (prolonged ileus, intractable nausea and vomiting, and acute gastric remnant dilation) have been reported in this population following surgery. No mortality was reported. Conclusion: The findings of the first systematic review and metaanalysis of this kind indicate that bariatric surgery leads to a remarkable weight loss in severely obese patients with T1D and results in significant improvement in insulin requirements and glycemic status. The favorable metabolic effects of bariatric surgery may facilitate medical management of T1D in the setting of severe obesity. However, results are limited to short follow-up time and are based on a small number of studies and individuals. Short term results of bariatric surgery in patients with T1D are promising but larger and longer studies are necessary.