A5087 - Anti-diabetic Effects of Ileal Transposition Surgery on Obese mice

Abstract

On the basis of the nutrient passage patterns, bariatric surgery is broadly divided into restrictive, malabsorptive, and/or metabolic procedures. It has been postulated that the early entry of nutrients into the distal small intestine after Roux-en-Y or other intestinal bypass procedures elicits a neuroendocrine response that causes improved glucose homeostasis, which is called “ileal break” mechanism. Ileal transposition (IT) is a hindgut procedure that produce weight loss and improve glycemic control by translocating a segment of the distal ileum proximally to the upper jejunum without altering the length of gastrointestinal tract or gastric restriction. The antidiabetic mechanisms of IT remain poorly understood. Ileal transposition has not been performed in the mouse model because of difficulty in constructing a functional small bowel anastomosis. The aim of this study was to evaluate the optimal surgical technique to construct an IT procedures in the mouse model and to examine the anti-diabetic effects of IT surgery on high-fat diet (HFD) induced obese mice.