A4951 The characteristics of ambulatory blood pressure in Chinese hypertensive patients with obstructive sleep apnea

Abstract

Objectives: To assess the characteristics of ambulatory blood pressure in the Chinese hypertensive patients with obstructive sleep apnea syndrome. Methods: PubMed, Cochrane Library, Embase, Science Citation Index, WanFang data, China National Knowledge Infrastructure database, and VIP were searched form these databases establishment to February 2018. Cross-sectional studies which directly compared Chinese hypertensive patients with and without obstructive sleep apnea (OSA) were included. The ambulatory blood pressure monitoring was used. The following parameters were analyzed: age, body mass index (BMI), apnea-hypopnea index (AHI), 24-h mean systolic blood pressure (SBP), 24-h mean diastolic blood pressure (DBP), day-time SBP, day-time DBP, night-time SBP, night-time DBP, pro-bedtime SBP, pro-bedtime DBP, morning SBP, morning DBP, and the number of patients with non-dippers. Data were extracted and analyzed by Cochrane Collaboration's RevMan 5.3 software. Results: Thirteen studies involving 1080 patients were included. There was no significant difference in age between the two groups, but the BMI in the OSA group was significantly greater than that in the non OSA group (P < 0.05). And AHI of hypertensive patients with OSA was significantly higher than that of patients without OSA (P < 0.05). Compared with hypertensive patients without OSA, all of the blood pressure were significantly increased except the pro-bedtime SBP and the pro-bedtime DBP. Moreover, the number of patients with non-dippers in hypertensive patients with OSA group was significantly more (P < 0.05). Conclusion: Chinese hypertensive patients with OSA not only showed a significant increase in the blood pressure level in each period, but also represented a higher proportion of non-dippers patients.