Abstract
Previous studies have reported greater antioxidant activity of lipophilic vs hydrophilic beta receptor blockers, and attributed this, in part, to biophysical membrane stabilization. Recent data indicate that lipophilic intercalation of propranolol into cellular endosomal/lysosomal compartments may contribute significantly to an important indirect antioxidant property of this agent involving lysosomal iron stabilization. Using cultured endothelial cells, the ability of propranolol to concentrate into acidic vesicles resulted in a more alkaline lysosomal pH due to the effect of the amino side chain of the drug.
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