A4252 The effect of left atrial size on the cognitive impairment of patients with atrial fibrillation

Abstract

Objectives: Left atrial (LA) size is an independent predictor of cardiovascular events.In patients with atrial fibrillation (AF), LA enlargement is also associated with the occurrence and recurrence of AF, but the relationship between LA size and cognitive function in patients with AF has not been reported. Methods: 297 patients with AF were selected from the second hospital of lanzhou university, the age average was 67.6 ± 8.4. According to the tertiles of left atrial diameter (LAD), they were divided into three groups(LAD≤33.8 mm group included 99 patients; LAD 33.9–39.7 mm group included 98 patients; LAD≥39.8 mm group included 100 patients), and then according to the MMSE score they were divided into no cognitive impairment group (n = 213) and cognitive impairment group (n = 84). LAD was obtained by echocardiography. To evaluate the effect of different LAD on cognitive impairment of AF patients by multivariate linear regression. Results: There are 84 patients of cognitive impairment with AF, accounting for 28.3%. With the increase of LAD, the incidence of cognitive impairment increased.When LAD≥39.8 mm, the incidence of cognitive impairment is 39% (P < 0.05). LAD was significantly associated with cognitive impairment (OR = −0.0893, 95%CI: −0.1570∼0.0216, P = 0.01), especially in the LAD≥39.8 mm group and LAD≥35 mm in women or LAD≥38 mm in male, LAD can independently increases the risk of cognitive impairment in patients with AF (OR = −1.3729, 95% CI: 2.4796∼0.2662, P = 0.016; OR = −0.9598, 95% CI: 1.8238∼0.0958, P = 0.03). Conclusion: LAD is an independent risk factor for cognitive impairment in AF patients.The incidence of cognitive impairment in AF patients increased with the enlargement of the LAD, especially language ability, concentration and computing powernd directional ability have been significantly reduce.