A4102 The relationships of the fractional excretion of uric acid with brachial-ankle pulse wave velocity and ankle brachial index in Chinese young adults

Abstract

Objectives: Elevated serum UA was intimately correlated with vascular stiffness and abnormal ankle brachial index. These correlations lost significance after adjustment for eGFR, indicating that the association of UA and baPWV or ABI might be driven by kidney function. UA is predominantly eliminated through the kidneys, and metabolic disorders can influence the clearance of UA. We investigated the putative correlation between FEUA and baPWV or ABI to determine to what extent the associations with UA were affected by renal function. Methods: We enrolled 2351 participants, who underwent general health screening in Hanzhong people's hospital. BaPWV and ABI were measured using a volume-plethysmographic apparatus. FEUA was divided into quartiles: Q1:FEUA≤3.07; Q2:3.07 < FEUA≤5.32; Q3: 5.32 < FEUA≤9.19; and Q4: FEUA> 9.19. Results: Lower FEUA predicted a higher prevalence of high baPWV and low ABI (p for trend <0.001). The respective ORs for high baPWV from the first to the third quartiles of FEUA were 1.777 (1.323, 2.387); 1.561 (1.158, 2.104); and 1.680 (1.250, 2.259). The prevalence of low ABI was greatly elevated with the decrement of FEUA [ORs for the first to third FEUA quartiles were 6.977 (2.062, 23.610); 5.123 (1.475, 17.790); and 2.685 (0.709, 10.171), respectively]. The association of FEUA and ABI was independent of related confounding factors. However, the association between FEUA and baPWV was greatly influenced by corresponding confounders, especially gender. The efficacy of FEUA in the prediction of low ABI was stronger than that of serum UA. However, serum UA was more powerful in the prediction of high baPWV. Conclusion: Kidney function exerted a profound influence on the relationship between UA and baPWV or ABI, revealing complex interactions among cardiovascular risk factors.