A41 EPHB4 RECEPTOR ACTIVATION BY ITS SPECIFIC LIGAND EPHRIN B2 INDUCED A REDUCED REMODELING PROCESS IN HUMAN SUBCHONDRAL BONE OSTEOBLASTS

Abstract

molecular chaperone activity (clusterin). Interestingly, other proteomic studies have identified clusterin and CILP-1 as being upregulated in early human OA. These biomarkers may be involved in early repair responses in cartilage and thus may be useful for the detection of early changes in OA. Acknowledgements: This work was supported by the BBSRC (BBS/S/M/2006/13141) and the WALTHAM Centre for Pet Nutrition.