Abstract
Objectives: Two men on antihypertensive therapy underwent unilateral radical nephroureterectomy for cancer of the renal pelvis. Methods: When the renal artery adventitia was stripped and cauterized just before renal artery ligation, hemodynamic monitoring revealed a gradual decrease of blood pressure in both patients. Results: This was presumably due to removal of renal artery sympathetic nerves, similar to the mechanism of catheter-based renal sympathetic denervation, although anesthesia, fluid infusion, and/or mesenteric traction may have had an influence. Conclusion: A similar strategy involving thoracolumbar sympathectomy was reported about 50 years ago. The clinically significant blood pressure reduction in these patients suggests renal denervation is effective.
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