A3705 Relationship between blood pressure variability and vascular elasticity and endothelial function in hypertensive patients

Abstract

Objectives: To investigate the Relationship between visit-to-visit blood pressure variability and vascular elasticity and endothelial function in hypertensive patients. Methods: Collecting 169 cases of essential hypertensive patients and all participants were followed every three months. VBPV was indicated by a standard deviation of visit-to-visit blood pressure .According to tertile of visit-to-visit systolic blood pressure variability (VSBPV), all participants were divided into low VSBPV group (n = 56), medium VSBPV group (n = 57) and high VSBPV group (n = 56). Results: The changes of FMD and NO in low VSBPV group was significantly higher than that of medium and high VSBPV group, the difference was statistically significant (P < 0.05). The changes of ET-1, cfPWV and AIx in the low VSBPV group, was significantly higher than that of medium and high VSBPV group, the difference was statistically significant (P < 0.05). The difference was statistically significant (P < 0.05). The change of IMT in high VSBPV group was significantly higher than that in medium VSBPV group, the difference was statistically significant (P < 0.05). Changes of FMD and NO were significantly negatively correlated with VSBPV (P < 0.05).Yet,Changes of ET-1, cfPWV, IMT and AIx were significantly positively correlated with VSBPV (P < 0.05).Changes of FMD and NO were negatively correlated with VDBPV (P < 0.05). Changes of ET-1 and cfPWV were positively correlated with VDBPV (P < 0.05). Controlling other variables, VSBPV was independently related to the rate of change of AIx, IMT, cfPWV, NO, ET-1 and FMD. Conclusion: The variability of visit-to-visit blood pressure is closely correlated with vascular elasticity and endothelial function in essential hypertension patients.