A3464 The clinical effect and contrast evaluation of office blood pressure,ambulatory blood pressure mornitoring on treatment of Yinxu-Yangkang type of primary hypertensives by TCM of Tianma Gouteng Yin

Abstract

Objectives: To observe the clinical curative effect and contrast evaluation of office blood pressure,ambulatory blood pressure monitoring on treatment of Yinxu-Yangkang type of primary hypertensives by TCM of Tianma Gouteng Yin. Methods: Total of 106 cases of Yinxu-Yangkang type of primary hypertension patients diagnosed by CBP and ABPM were randomly selected to take Tianma gouten Yin with 150 ml (tid) for 4 weeks, Then, the clinical curative effect, changes in CBP and 24 hours ABP were compared. Results: The clinical symptoms of patients were improved significantly and side effects were less; The DBP reducing at night was not significant difference (p > 0.05);All of blood pressure variability, nocturnal blood pressure drop rate and heart rate were not significant difference before and after treatment (p > 0.05); ***All of 24-hour average blood pressure, daytime and nighttime (only SBP) mean blood pressure,daytime and nighttime (only SBP) blood pressure load values had significant difference (p < 0.01 or p < 0.05) before and after treatment (p < 0.01 or p < 0.05);The office blood pressure is higher than the mean ambulatory blood pressure after treatment. Conclusion: It had better improving efficacy of clinical symptoms and tolerability, and less side effects in treatment of hypertension patients byTianma gouten Yin; The reasons and possiblities of lower antihypertension effect for DBP in nighttime of Tianma gouten Yin on ambulatory blood pressure may be follows:The evidence of dose-effect relation of evidence-based medicine is still short of; blood drug concentration is not easy to keep constant in nighttime;or the bioavailability is differences obviously. To explore some new taking ways of traditional Chinese medicine in treatment of hypertension are necessary.