A3101 The association between early morning hypertension and stroke –related dementia in the elderly

Abstract

Objectives: We evaluated the prevalence of the pattern of high blood pressure and effects of arterial stiffness, pulse wave velocity (PWV) and wave reflections on central aortic pressure (CAP) in hypertensive patients with dementia. Methods: We analyzed 150 hypertensive patients with dementia, investigated using 24hr ambulatory blood pressure monitoring (ABPM). Among the HT, classified as early morning hypertension (EMHT) (early morning BP: above 135/85 mmHg and night-time BP: below 120/70 mmHg), Night HT (NHT)(Daytime BP: below 135/85 mmHg and night-time BP: above 120/70 mmHg). And using radial artery applanation tonometry, aortic pulse analysis was performed. Results: 85 patients was observed HT with stroke related dementia. EMHT was found in 55.6% of patients. Compared with patients with both EMHT and NHT, EMHT had higher aortic pulse wave velocity (PWV) and augmentation index (AI) and AI75 (AI to HR 75 beat/min), ASP (Central aortic systolic pressure) and pulse pressure were also higher in the EMHT. Conclusion: Our study showed that EMHT could have increased stroke related dementia and especially, early morning systolic BP, might be risk factor for cognitive decline. Hence active anti-hypertension treatment benefits prevention of cognitive dysfunction in stroke related dementia.