A3089 Study on the Association of TBXAS1 Gene Polymorphisms with Stroke of Metabolic Syndrome

Abstract

Objectives: To investigate the genotypic and allelic distributions of TBXAS1 gene in Chinese Han population residing in Shandong Province and determine the association of the TBXAS1 gene polymorphism with MS and explore the relationship between the TBXAS1 gene polymorphisms and the endpoints of MS. Methods: A total of 3585 eligible subjects were obtained, of which 1592 cases were normal controls, 1993 cases were patients with MS;the subjects underwent 5 years follow-up. Results: There were no significant differences in the distribution of genotypic frequencies of −212515A/G between MS group and controls (all P > 0.05). There were no significant differences in gender between MS group and controls (all P > 0.05). Compare with the control group, the BMI, WC, SBP, DBP, TC, TG, LDL-C, FPG and alcohol consumption were significantly higher in MS group (P < 0.001), the HDL-C and smoking were significantly lower (P < 0.05);There were no significant differences in gender, age, TC and LDL-C between MS group and controls (all P > 0.05). Compare with the control group, (2) In MS population, there was significant differences between the −212515A/G polymorphism of TBXAS1 gene and stroke, but no significant differences between the −212515A/G polymorphism of TBXAS1 gene and other endpoint Conclusion: No significant differences in the distribution of genotypic frequencies of −212515A/G are found between MS group and controls, so there are no relationship between MS and genotypes of −212515A/G polymorphism of TBXAS1 gene. The individuals who with −212515 G allele of TBXAS1 gene have high risk and high cost of stroke, especially combined with MS.