A2830 Serum soluble (pro)renin receptor concentration is correlated with organ dysfunctions in patients with primary aldosteronism

Abstract

Objectives: Primary aldosteronism (PA) is characterized by autonomous production of aldosterone by adrenal lesions and leads to hypertension. It is known that excess of aldosterone causes organ dysfunctions, but the underlying mechanism to cause organ dysfunctions still remains undetermined. (Pro)renin receptor[(P)RR] binds to both renin and its precursor prorenin to activate tissue renin-angiotensin system (RAS). (P)RR is cleaved by furin to generate soluble (pro)renin receptor [s(P)RR], and thus blood s(P)RR concentration is a candidate biomarker reflecting the status of the tissue RAS. In this study, we investigated the relationships between serum s(P)RR concentration and indices of organ dysfunctions in PA patients. Methods: We examined serum s(P)RR concentration in PA patients who were either without antihypertensive medications or were treated only with calcium channel blockers. We also evaluated the relationships between serum s(P)RR concentration and indices of organ dysfunctions such as high-sensitivity CRP (hsCRP), cardio-ankle vascular index (CAVI), eGFR, and BNP. Results: A total of 124 patients (76 males, 54.9 ± 12.2 y.o.) were enrolled. Serum s(P)RR concentration was significantly positively correlated with hsCRP (r = 0.44, p < 0.05), CAVI (r = 0.39, p < 0.05), and BNP (r = 0.25, p < 0.05), and was significantly negatively associated with eGFR (r = 0.42, p < 0.05). Plasma aldosterone concentration (PAC) did not show significant relationships with these indices. Conclusion: In PA patients, serum s(P)RR concentration but not PAC showed associations with organ dysfunctions. Increased tissue RAS may be associated with the cause of organ dysfunctions in these patients. Further investigations are needed to clarify the underlying mechanisms by which serum s(P)RR concentrations are associated with organ dysfunctions.