A2528 The Disease Burden of Atrial Fibrillation in China

Abstract

Objectives: Atrial fibrillation (AF) is the most common type of arrhythmia which is a significant public health issue. We aimed to determine the disease burden of AF in China. Methods: A stratified multistage random sampling method was used to obtain nation-wide sample collections representing the general population over 18 years across China for a hypertension prevalence survey. For the AF prevalence study, selected 262 urban and rural areas were stratified into eastern, middle and western regions according to both geographical location as well as economic level, 34,994 people aged 35 years or older were enrolled from different regions. The AF patients were detected by electrocardiogram (ECG) during the survey or medical history taking. The quality of life in AF patients was assessed by a questionnaire similar to EQ-5D to estimate the weight of disability. Disability Adjusted Life Years (DALY) was then calculated by adding Years of Life Lost (YLL) to Years Lived with Disability (YLD). Results: Overall, 31,230 samples were included in the final analysis, the weighted prevalence of AF in the Chinese population aged 35 years or older was 0.71%, was higher in rural than in urban (0.75% vs. 0.63%), and was highest in eastern area (Figure.1). 34% of AF patients were newly diagnosed in the survey and unaware of their pathological condition beforehand. The AF prevalence gradually, but significantly, increased with age, ranging from 0.10% in the 35–45 age group up to 2.35% in participants aged over 75 years old (P < 0.001). The health-related quality of life was impaired in Chinese AF patients with an overall utility value of 0.53. The total DALY of Chinese AF patient is estimated to be 665,399.78. Conclusion: This nation-wide study indicated that the disease burden of AF in the general Chinese population was a significant