A-247 Overall Test Battery Means from ANAM4 TBI-MIL and D-KEFS: A Within-Subject Comparison of a Traumatic Brain Injury Cognition Composite Score

Abstract

Abstract Objective Several cognition composite scores have been developed for potential use in traumatic brain injury clinical trials. This analysis examined the equivalence of overall test battery mean (OTBM) from two different test batteries administered consecutively to the same subjects. Methods Soldiers were administered the Automated Neuropsychological Assessment Metrics (version 4) TBI-MIL (ANAM4) computerized battery and D-KEFS as part of a larger study comparing within-subject performance from different neuropsychological test batteries. Data from 121 soldiers with complete and valid data on both ANAM4 and D-KEFS and no recent TBI were used in this analysis. OTBMs were calculated for ANAM4 and the seven D-KEFS achievement scores. The OTBMs from the 121 soldiers were ranked from lowest to highest and the percentile rankings from each battery were compared. For each soldier, the differences between the percentile ranks from each battery were also calculated. Results Only 53.8% of soldiers who scored below the 20th percentile on ANAM4 also scored below the 20th percentile on D-KEFS. Furthermore, only 47.8% of soldiers who scored at or above the 80th percentile on ANAM4 also scored in that range on D-KEFS. Some soldiers’ performance on each battery diverged by large amounts, for example from 59.5 to 82.6 percentage points. Correlation analysis revealed that the OTBMs and percentile rankings from both batteries were modestly correlated (OTBM r = 0.515, p < 0.001, percentile rank r = 0.499, p < 0.001). Conclusion These results suggest that comparing similar cognition composites from different neuropsychological test batteries from different studies in a meta-analytic manner may not be feasible due to psychometric difference between batteries.