A2430 Glomerulomegaly and blood pressure may predict renal progression after 10 yrs in IgA nephropathy

Abstract

Objectives: We previously reported that blood pressure (BP) and glomerular size are related to pathologic findings and renal function in IgAN. We reanalyzed these effects on long-term renal progression. Methods: We analyzed renal biopsy specimens and clinical information in patients with IgAN (n = 34). Glomerular surface area (GSA) was determined using a computer imaging analyzer. Results: There were significant correlations between mean or maximal GSA and age, body mass index, systolic and diastolic BP, eGFR, and pathological findings including glomerulosclerosis, interstitial fibrosis, and tubular atrophy. The group with higher GSA had higher BP, pathological grade and lower eGFR. Twenty-two patients with initial normal serum creatinine levels were followed up for >10 yrs. As well as GSA was reversely correlated with final eGFR, GSA and initial BP were higher in the progressor group (n = 6; two on hemodialysis) than in the normal group (n = 16). Conclusion: These results suggest that glomerulomegaly and BP may predict the long-term renal progression in IgA nephropathy.