A18970 Which one is matter in modulating novel cardiovascular risk factors among chronic kidney disease patients

Abstract

Objectives: The interaction among novel cardiovascular disease (CVD) risk factors such as endothelial dysfunction, micro-inflammation, and oxidative stress is believed to be the determinant of the long-term outcomes in Chronic Kidney Disease (CKD). As hypertension is one of the controllable CVD risk factors, it is important to know whether high blood pressure modulate course other novel CVD risk factors. This study aimed to investigate the interaction of increased blood pressure with CVD risk factors in CKD. Methods: The data of resting blood pressure and renal functions of CKD patients in three hospital in Surabaya were consecutively collected along with Malondialdehyde (MDA) and Total Antioxidant Capacity (TAC) as oxidative stress markers; Serum hs-CRP, Lymphocyte-to-Monocyte ratio and Platelet-to-Lymphocyte ratio as inflammatory markers; and urine albumin-to-creatinine ratio (ACR) as renal disease marker. The participants were grouped based on their systolic and diastolic blood pressure (SBP and DBP). Results: This cross-sectional study revealed that high SBP associated with higher MDA (P < 0.05), hs-CRP (P < 0.05), Platelet-to-Lymphocyte ratio (P < 0.05), and ACR (P < 0.0001); in contrast, with lower Lymphocyte-to-Monocyte ratio (P < 0.05) and TAC (P < 0.0001). High DBP associated with higher ACR (P < 0.05) and lower TAC (P < 0.05). Conclusion: The increased blood pressure, whether both or one of SBP or DBP, were significantly associated with inflammation, oxidative stress and albuminuria in our study population. Thus, optimal blood pressure control may be one of strategies to prevent inflammation and oxidative stress among CKD patients by taking into accounts of controlling both SBP and DBP.