A18581 The association of metabolic syndrome and chronic kidney disease in patients with hypertension in China—a cross sectional study

Abstract

Objectives: In a cross-sectional study, we investigated the metabolic syndrome in patients with hypertension and the association of chronic kidney disease (CKD) with metabolic syndrome. Methods: Totally 4286 patients with hypertension were enrolled from the out-patient clinic of 15 cities in China during 2017–2018. Results: The prevalence of CKD (estimated glomerular filtration rate < 60) was 12.74% in this population. There was no difference in the systolic blood pressure (SBP) between CKD and non-CKD (141.03 ± 20.53 vs 141.44 ± 17.34 mmHg, p = 0.621). Diastolic blood pressure (DBP) was higher in CKD patients (85.13 ± 15.15 vs 83.51 ± 12.05 mmHg, p = 0.005). BMI was higher in CKD patients (25.61 ± 5.97 vs 24.78 ± 3.66, p < 0.001). More patients were under lipid lowering medication in CKD group compared to non-CKD group (66.06% vs 49.51%, p < 0.001), but LDL-C level was much higher in CKD group (3.03 ± 1.69 vs 2.80 ± 1.00 mmol/L, p = 0.001). The prevalence of Diabetes Mellitus (DM) was higher in CKD group (28.33% vs 21.42%, p < 0.001) and HbA1C% was also higher in CKD with DM compared to non-CKD with DM (8.06 ± 2.11vs 7.58 ± 2.09, p = 0.055). After adjusting for age and gender, LDL-C (OR = 1.21, 95%CI 1.09–1.33, p < 0.001), DM (OR = 1.36, 95%CI 1.11–1.68, p = 0.004) and BMI (OR = 1.05, 95%CI 1.03–1.07, p < 0.001) remained strongly associated with the prevalence of CKD. Conclusion: In China, metabolic syndrome was not well managed in patients with hypertension especially in those with CKD. Metabolic syndrome was strongly associated with CKD even if the average BP was similar.