A17942 Vitamin D deficiency would be a potential risk factor of severe obstructive sleep apnea in males aged than 45-year-old

Abstract

Objectives: Lower 25-hydroxyvitamin D (25[OH]D) concentration was hypothesized to be associated with obstructive sleep apnea (OSA), but the exact role of 25[OH]D in OSA was not consistent. This study tried to explore further association between Vitamin D deficiency with OSA. Methods: 324 hospitalized individuals in Sleep Monitoring Center of People's Hospital of Xinjiang who successfully completed the overnight polysomnography, serum 25(OH)D measurement, and collection of demographic and comorbidity data were consecutively selected from April to Decemer,2016. The severe sleep apnea was defined by apnea hyponea index (AHI) of 30/h or more, the non-OSA was defined as AHI < 5/h. Results: 248 out of 324 patients (76.5%) patients had 25[OH]D level < 20 ng/ml. The patients were divided into two groups based on the level of 25[OH]D. No significant difference of the detection rate of severe OSA between 25[OH]D deficiency group and 25[OH]D > = 20ng/ml group in the total population. But, in patients aged > 45-year-old, it showed that 51.1%(70/137) cased with 25[OH]D < 20ng/ml were detected more severe OSA, which was significantly greater than that in patients with 25[OH]D> = 20ng/ml subgroup (31.0%). Besides, in age older than 45yr group, the RDI, obstrutive events and index, as well as total apnea events and index showed significant higher in 25[OH]D < 20ng/ml group. Logistic regression model showed that in males, the lower 25[OH]D may a risk factor of OSA. Conclusion: Among males, the severe OSA was largely explained by the lower 25(OH)D, but aged > 45yr played as a risk factor of OSA in females. The gender difference of proportion of OSA and estrogen level should be considered to explain the results. Anyway, our results indicated the treatment of VitD deficiency has potential effective benefits for severe OSA.