A17864 Functional state of the kidneys in patients with arerial hypertension with concomitant osteoarthritis and obesity

Abstract

Objectives: Metabolic syndrome is associated with 2,6–5,8 times higher risk of development of renal dysfunction (RD) that is a trigger and consequence of some events in arterial hypertension (AH) co-existing frequently with osteoarthritis (OA) in elderly people. Less number of investigations estimate frequency and grade of renal comorbid pathology in case of co-morbid pathology Methods: 100 patients (35 – AH II stage, 35 – OA and 30 – AH+OA). Obesity:optimal BMI = 50:50 in every group. Clinical examination, ultrasound, urinalysis, GFR, K+ and Na+ absorption and secretion were done Results: We detected significant changes of proteinuria, GFR, Na+ renal excretion and absolute reabsorption Patients with OA, normal BMI and AH had no signs of proteinuria. 28% obese people with AH had microalbuminuria. In AH+OA with normal BMI daily protein excretion increased 5.9 times comparing isolated AH, and 14.4 times- in obesity. GFR changed similarly: 79,04 ± 5,42 and 67,04 ± 4,62 ml/min in AH +OA with optimal BMI and obesity, that was 29,4% and 37,9% less comparing AH (88,04 ± 3,67 and 96,04 ± 4,38 ml/min with optimal BMI and obesity) and 42,8%/30,2% - less comparing OA group. Absolute Na+ reabsorption increased 7,2%) and daily excretion decreased by 6,7%, that was significant (ρ < 0,05) in patients with AH + OA and obesity comparing isolated pathology and comorbidity in normal BMI patients. Conclusion: Co-existance of AH and OA, especially at the backgrounf of obesity, is characterised by frequent and much worse course of renal dysfunction. That shuold be taken into account when composing examination schedule and choosing treatment.