A17455 Predictors of antihypertensive medical treatment adherence decline

Abstract

Objectives: To reveal factors, that predict antihypertensive medical treatment adherence decline in patients with arterial hypertension Methods: We interviewed randomly selected 256 patients with arterial hypertension, who visited one of the outpatient departments in Tyumen region, Russia. Interview was performed within 3 months after outpatient department visit. Adherence was measured using the eight-item Morisky Medication Adherence Scale. The degree of adherence was determined according to the score resulting from the sum of all the correct answers: high adherence (eight points), average adherence (6 to < 8 points) and poor adherence (< 6 points). After 12 months (+/- 3.2) patents were interviewed once again. Decline in adherence was considered minus 2 MMAS-8 points. Results: At the baseline 21.9% were highly adherent to treatment (14.6% males versus 25.9% females, p < 0.05). 45.7% had average adherence (39.0% males versus 48.9% females). 32.4% were poorly adherent to treatment (46.3% males versus 25.3% females, p < 0.01). After 12 months 15.2% were highly adherent (p > 0.05), 25.0% had average adherence (p < 0.01), 59.8% had poor adherence (p < 0.01). Factors increasing risk of adherence decline were male sex (RR – 2.626, 95%CI 1.136–6.072, p < 0.01); number of medicines prescribed above 2 (RR – 2.56, 95%CI 1.98–4.75, p < 0.05), 3 and more comorbid conditions (RR – 2.017, 95%CI 1.163–4.382, p < 0.01), smoking status (RR – 2.317, 95%CI 1.263–5.367, p < 0.01), low income (RR – 1.736, 95%CI 1.06–4.201, p < 0.05), single marital status (RR – 1.436, 95%CI 1.116–3.521, p < 0.05), elevated level of depression (RR – 1.28, 95%CI 1.002–4.201, p < 0.05). Conclusion: As the results of our research we found the factors that predict adherence decline in patients with AH, living on the territory of Tyumen region, Russia.