A17136 Research on Vascular Endothelial Function and Influencing Factors of Middle - aged Hypertensive Patients at First Diagnosis

Abstract

Objectives: The aim of this study was to investigate the relationship between vascular endothelial function and influencing factors,such as blood pressure variability,PWV,central blood pressure,biological/ biochemical/behavioral factors,in the young and middle- age hypertensive patients at first diagnosis Methods: Patient information was collected that included basic informationand living habits. We had available information on patients’ clinical characteristics at first diagnosis, including blood pressure, fasting blood glucose, glycosylated hemoglobin, blood lipid level, sCRP, HCY,IMT,CASP,AIx,PWV, urinary protein, BPV,systolic pressure of 24 hours, and FMD. Results: To analysis of factors that affect vascular endothelial function, whether sedentary, systolic blood pressure coefficient of variation, IMT, CF, CR results for P < 0.05 for the difference was statistically significant. After adding biological factors, biochemical factors, blood pressure, arteriosclerosis and other factors, multivariate analysis of grouped FMD the result showed that systolic blood pressure, arteriosclerosis and other factors, multivariate analysis of grouped FMD the result showed that systolic blood pressure coefficient of variation and whether sedentary were excluded from the other factors was significantly correlated (P < 0.05) Conclusion: Sedentary, obesity, TG,urine microalbumin, glycosylated hemoglobin were associated with the vascular endothelial function and might serve as risk factors of endothelial dysfunction in the middle-aged patients with hypertension. These data suggested that these patients should pay attention to the health life habits besides focused on the blood pressure. In addition, patients with elevated IMT, CF and CR should take endothelial function seriously to prevent cardiovascular events