A16790 Preparation of capsules from zingiber officinale roscoe aqueous extracts and evaluation of the cardiovascular effects of the plant as add-on therapy, in patients with type 2 diabetes mellitus

Abstract

Objectives: To study cardiovascular effects of daily administration of an aqueous extract of Zingiber officinale Roscoe in type 2 diabetes patients over a 6-week period Methods: We conducted a non-randomized single-arm clinical trial over a period of 8 months in type 2 diabetes mellitus patients with HbA1c between 42 to 64 mmol/mol (6–8%) and unchanged anti-diabetic treatment three months prior to inclusion. Intervention consisted in the administration of powdered aqueous ginger extracts in the form of capsules at a dose of 1 g twice daily, for 6 weeks. Before and after intervention we measured body composition by bioimpedance, office blood pressure, fasting blood sugar, glycated haemoglobin, lipid profile, liver function tests, serum creatininaemia and full blood count. We also performed 24-hour Ambulatory Blood Pressure Measurements, electrocardiography, and transthoracic heart doppler ultrasound with the measurement of e′ velocity, E/A ratio, E/e′ ratio, A wave velocity and E wave velocity, to assess changes in diastolic function. Results: We included 24 patients (18 females) aged 54 + /- 10 years, with 7 years diabetes duration and 49.7 mmol/mol baseline HbA1c. The intervention induced a 3.5% drop in BMI, a 3.1% drop in fat mass, − 10.9% HbA1c and − 25% triglycerides. We equally found a 12.5% drop in A Wave velocity (cm/s), non-significant 20% increase in e′ wave velocity (cm/s), 16.7% increase in E-Wave velocity (cm/s) and a 3.4% non-significant increase in duration of isovolumetric relaxation. ABPM showed a 63.9% increase in systolic and 7.2% increase in diastolic dipping patterns. Conclusion: Six weeks add-on Zingiber officinale has significant metabolic effects with trends towards improvement of blood pressure profile and diastolic function in patients with type 2 diabetes mellitus.