A15972 The characteristic of adrenoceptor related gene polymorphism of hypertension in northwest region Han people of China

Abstract

Objectives: The aim of this study is to investigate the the characteristic of adrenoceptor related gene polymorphism of hypertension in northwest region Han people of China. Methods: Genetic analysis of the Arg347Cys polymorphism was conducted by polymerase chain reaction/restriction fragment length polymorphism. We have compared cardiovascular risk variables and genotypes using ANOVA, and Chi-square test for univariate comparisons and logistic regression for multivariate comparisons. A case-control study comprising 576 hypertension cases and 576 controls from the general population of Gansu province in China was used to evaluate the association of 13 adrenoceptor tagging single nucleotide polymorphism (tagSNPs) in northwest region Han people of China. Genetic analysis of the adrenoceptor related gene polymorphism was conducted by polymerase chain reaction/restriction fragment length polymorphism Results: Three SNPs were significantly associated with systolic blood pressure (SBP), including rs17327624 (p = 6.167 × 10–4, beta = 5.650), rs3789243 (p = 4.331 × 10–3, beta = 2.800), and rs4148734 (p = 3.514 × 10–3, beta = 3.692). Rs17327624 (p = 2.818 × 10–4, beta = 2.753) and rs3789243 (p = 6.345 × 10–3, beta = 1.497) were significantly associated with diastolic blood pressure (DBP) and rs17327624 was significantly associated with hypertension (p = 1.746 × 10–4, OR = 1.605). These three SNPs (rs17327624, rs3789243 and rs4148734) were also associated with hypertension in female subjects but no significant signal was detected in males. Conclusion: Our results suggest that ABCB1 polymorphisms may contribute to the blood pressure variation in northwest region Han people of China and the effect may be specific in females.