A15570 Micro-albuminuria in Stage 2 Hypertensive patients with Left Ventricular Hypertrophy

Abstract

Objectives: Microalbuminuria (MA, albuminuria: 20–200 μg min-1) is associated with several cardiovascular risk factors including left ventricular hypertrophy (LVH). The relationship, usually assumed to reflect an increased blood pressure (BP) load on the heart and the kidney. To evaluate this relation between MA and LVH, left ventricular mass index (LVMI) was deter-mined in stage 2 hypertensive patients with LVH. Methods: Hundred cases of non diabetic patients with stage 2 hypertension and left ventricular hypertrophy visiting outdoor and indoor patients of Mayo Hospital Lahore were registered. Microalbuminuria was detected using standardized dipstick technique (MICRAL, Roche, USA) and recorded in mg/dL. Left ventricular hypertrophy was deter-mined by measuring LVMI in gram/m2 using GE Logic pro 500 echocardiography with color Doppler. All this information was collected through a specially designed proforma Results: Microalbuminuria was present in 65% of the hypertensive individuals with LVH. When the occurrence of microalbuminuria was analyzed according to the different clinical parameters like age and gender and duration of hypertension, a significant correlation was found with age and duration of hypertension, but no significant relation was found with either gender Conclusion: There is high frequency of microalbuminuria in hypertensive individuals with left ventricular hypertrophy. This is associated with advanced age, duration of hypertension and degree of left ventricular hypertrophy. So microalbuminuria is an important predictor of cardiovascular morbidity and mortality in hypertensive patients with left ventricular hypertrophy and should be checked routinely in all hypertensive patients, regardless of the presence of diabetes.