A15410 Cardiometabolic risks clustering associated with impaired bone mass in central obese children

Abstract

Objectives: An increasing evidence has supported the association of bone mass with obesity and cardiometabolic risks. However, the combined contribution of obesity and cardiometabolic risk clustering to the bone mass remains unclear. Methods: A total of 8,780 participants, 6–18 years old were studied using data from a cross-sectional study conducted in urban Chinese cities in 2013–2014. Total body bone mineral content excluding head (BMCEH), total body lean mass, total and regional body fat were measured by dual-energy x-ray absorptiometry. Cardiometabolic indices, including blood pressure, fasting glucose, triglyceride and high-density lipoprotein were obtained. Participants were classified into four groups according to their cardiometabolic and obesity status, which were defined by the presence/absence of more than 2 abnormalities and with/ without excessive total body fat percentage (FMP) or android-to-gynoid fat maratio (AGR). Results: In boys, after controlling for age, height and lean mass, FMP, AGR, triglyceride and glucose were negatively associated with BMCEH, while high-density lipoprotein were positively associated with BMCEH (all p < 0.05). Similar relationships were also observed in girls, except for that with FMP (r = 0.142, p < 0.001) and glucose (r = −0.016, p = 0.318). Compared with cardiometabolic healthy non-obese boys, decreased levels of BMCEH were found in cardiometabolic healthy and unhealthy obese individuals, irrespective of obese status defined by FMP or AGR. In girls, similar patterns were only found in AGR defined obesity. For FMP defined obesity, cardiometabolic healthy obese girls demonstrated higher BMCEH than their healthy non-obese counterparts. Conclusion: Being obese with cardiometabolic abnormalities, particularly with central obesity may adversely influence bone mass in children.