A1458 Effect of Salt Intake on Plasma and Urinary Uric Acid Levels in Chinese Adults

Abstract

Objectives: Uric acid (UA) has been proposed as an important risk factor for cardiovascular and renal morbidity. We conducted an interventional trial to assess the effects of altered salt intake on plasma and urine UA levels and the relationship between UA levels and salt sensitivity in humans. Methods: Ninety subjects (18–65 years of age) were selected from a rural community of northern China. All subjects were sequentially maintained on a normal diet for three days at baseline, a low-salt diet for 7 days (3.0 g/day, NaCl), and a high-salt diet for an additional 7 days (18.0 g/day of NaCl). Results: The plasma UA levels were significantly increased from baseline to the low-salt diet and decreased from the low-salt to high-salt diet. In contrast, the daily urinary levels of UA were significantly decreased from baseline to the low-salt diet and increased from the low-salt to high-salt diet. Also, 24-h urinary sodium excretions were inversely correlated with the plasma UA, and positively correlated with the urinary UA excretions. Additionally, salt-sensitive subjects were associated with a significantly higher plasma UA changes in comparison to salt-resistant subjects, and a negative correlation between the degree of salt sensitivity and plasma UA difference was observed. Conclusion: The present study indicates that variations in dietary salt intake affect the plasma and urine, and plasma UA may be involved in the pathophysiological process of salt sensitivity.