A14000 Sex differences in blood pressure variability and anxiety or depression state in the middle-aged untreated patients with uncomplicated grade 1–2 essential arterial hypertension

Abstract

Objectives: to investigate sex differences in blood pressure variability (BPV) and its association with anxiety or depression severity in the middle-aged naive patients with grade 1–2 essential arterial hypertension (EAH). Methods: we examined 60 naive patients with EAH (31 men, 29 women) and 44 sex- and age-matched healthy individuals (21 men, 23 women). All participant underwent ambulatory blood pressure monitoring and psychological assessment using Hamilton rating scale for anxiety and depression. Results: in hypertensive men nighttime systolic BPV (sBPV) and nighttime diastolic BPV (dBPV) were significantly (p < 0,05 and p < 0,001, respectively) higher compared to normotensive men. In hypertensive women day- and nighttime sBPV, day- and nighttime dBPV were significantly (p < 0,05; p < 0,001; p < 0,05; p < 0,001, respectively) higher compared to normotensive women. In hypertensive women anxiety (2,8 ± 3,8) and depression (1,7 ± 3,0) score were significantly (p < 0,001 and p < 0,01, respectively) greater than analogical one in normotensive women (0,2 ± 0,8 and 0,1 ± 0,5, respectively). Anxiety (1,1 ± 3,3) and depression (0,3 ± 1,2) severity in hypertensive men were significantly lower (p < 0,01 and p < 0,001, respectively) compared to the same parameters in hypertensive women. Conclusion: middle-aged untreated women with grade 1–2 EAH has more pronounced disturbances in BPV compared with age- and hypertensive history-matched men, and these abnormalities may be associated with their emotional state.