Abstract
Elevation in the afterload (perfusion) pressure worsens myocardial infarct size and functional recovery following an ischemia reperfusion insult. We tested the hypothesis that augmented calcium (Ca2+) overload contributes to the effect of high afterload pressure. Hearts of male Sprague-Dawley rats (12-week-old) underwent 40 min. of regional ischemia followed by 2 hrs. of reperfusion; afterload pressure was set at either 80 or 160 cm H2O. The heart was perfused with buffer either lacking or containing 10 μM of diltiazem (L-type Ca2+ channel blocker), 0.3 μM of mibefradil (T-type Ca2+ channel blocker) or 10 μM of cariporide (inhibitor of Na+/H+-Na+/Ca2+ exchanger combination).
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