A1.29 Normal and rheumatoid arthritis neutrophil extracellular TRAPS are both pro- and anti-inflammatory via mechanisms involving the C1Q complement protein but independently of ACPA, ll-37 or the inflammasome

Abstract

Background and objectivesActivated neutrophils (PMN) form neutrophil extracellular traps (NET), expelled chromatin fibres. NETosis is dependent on citrullination and may be pathogenic in rheumatoid arthritis (RA), which is characterised by...