A1213 Relationship between Blood Pressure Variability and Arterial elasticity in patients with stroke

Abstract

Objectives: To explore the correlation between Blood Pressure Variability and Arterial elasticity in patients with stroke. Methods: 183 stroke patients and 61 non-stroke individuals were enrolled according to the inclusion and exclusion criteria. 24hABPM, Carotid-radial pulse wave velocity and carotid artery ultrasound were conducted. All indicators of Blood Pressure Variability were calculated from 24 hour ambulatory blood pressure. Results: Compared with non-stroke subjects, MBPS, SD of SBP, CV of SBP, SBPF, CrPWV, IMT and stiffness index β showed significant increasing in ischemic and hemorrhagic stroke individuals, P < 0.05. For CrPWV and stiffness index β, there were statistically significant relationships with MBPS, SD of SBP, wSD of SBP, CV of SBP, SBPF and DBPF. IMT was closely related to MBPS, SD of SBP, CV of SBP, SBPF. The factors remarkably associated with CrPWV in logistic regression, including MBPS, SD of SBP, SBPF, CV of SBP, wSD of SBP, smoking and TCHO. IMT was significantly limited by SD of SBP, CV of SBP, SBPF, smoking and HDL, while sSD of SBP, CV of SBP, SBPF, smoking and DBPF were observed as important influence factors with stiffness index β. Conclusion: BPV showed significant relationship with vascular elasticity in stroke patients, and the protection of arterial elasticity and function is due to the reduction of BPV.