A117 - Weight Regain In Roux-En-Y Gastric Bypass Late Postoperative – Gut Hormones Role

Abstract

The RQ values increased significantly in the three groups from baseline to the end of the 3-hour postprandial (PP) period. The DIT adjusted for body weight was not significant in the OB group at any PP moment compared to the basal moment. In the healthy and weight regain groups, this increase was significant until the end of the 3-hour period. The average values of the AUC for RQ and RMR in absolute terms did not differ between groups (p 1⁄4 0.3111 and p 1⁄4 0.1131, respectively). But, the mean AUC values for DIT adjusted for body weight differed between the groups, in that the average AUC value was significantly greater in the HW group than in the WR and the OB groups (p o0.0001 for both). The mean AUC value for DIT adjusted for body weight in the WR group was not significantly different from the OB group (p 1⁄4 0.6369). Conclusion: DIT appears to be increased in patients with adequate weight loss after RYGBP. The WR group showed similar DIT values to those of the OB group. The RQ values did not differ between groups. Prospective studies are needed to determine if the decreased DIT values in weight regain function as a cause or consequence of weight regain after RYGBP.