A11684 Ambulatory parameters of blood pressure in patients with different etiology of end-stage renal disease

Abstract

Objectives: to study parameters of the peripheral and central hemodynamics during interdialytic period in patients with different etiology of end-stage renal disease (ESRD) Methods: in 68 patients with ESRD on maintenance hemodialysis (HD) 44-hour parallel ambulatory monitoring of blood pressure (BP) in the brachial artery and the aorta in interdialytic period was performed using a validated oscillometric device. The results were estimated depending on the etiology of ESRD: due to the primary kidney diseases or arterial hypertension (AH) and/or diabetes mellitus (DM). Mann-Whitney test was considered significant if p < 0,05 Results: patients with ESRD due to AH and/or DM to ESRD had higher levels of clinical systolic BP (SBP) before (156 [143;168] and 146 [136;155] mm Hg.) and after a session of HD (154 [140;169] and 146 [137;155] mm Hg.); p < 0,05. These patients also had higher values of peripheral 44-hour SBP (149 [138;160] and 139 [132;147] mm Hg.), pulse BP (PBP) (65 [56;74] and 60 [54;66] mm Hg.), central night SBP (132 [122;143] and 125 [116;133] mm Hg.); p < 0,05. Only in the group of patients with ESRD due to AH and/or DM peripheral (152 [141;163] and 147 [136;158] mm Hg.) and central SBP (137 [125;148] and 131 [121;141] mm Hg) in the 2nd interdialytic day was higher than in the 1st day; p < 0,05. The peripheral and central day and night SBP and pulse BP were also higher. In the group of patients with primary kidney diseases the level of the central SBP at night was higher in the 2nd interdialytic day compared to the 1st (131 [121;142] and 126 [116; 135] mm Hg., p < 0,05) Conclusion: patients with ESRD due to AH and/or DM had higher levels of clinical and ambulatory BP