A11316 The correlation analysis between urinary renalase and early renal damage in essential hypertension

Abstract

Objectives: To preliminary study the relationship among urinary renalase, blood pressure and the level of early renal damage in primary hypertension and to discuss significance of urinary renalase in primary hypertension with early renal damage by observing urinary renalase. Methods: With 164 patients diagnosed as primary hypertension(84 with early renal damage and 80 not) were,eventually,recruited in the outpatient room and the ward of the Cardiology Department of 3rd Xiangya Hospital from 09.2015 to 01.2016,when as well as 81 healthy adults. General information and biochemical data were collected. Urinary renalase,urine albumin and urine creatinine was detected. The statistical software SPSS 19.0 were used to analysis the data. Results: 1. The hypertension with early renal damage group (n = 80)had lower urinary renalase content (ug/ml) compared with the hypertension without early renal damage group (n = 84)and the healthy control group (n = 81) (1.74 ± 0.25 vs 2.32 ± 0.24 vs 4.22 ± 0.29, P < 0.05), with statistically significant differences.2. Urinary renalase was found in negative correlation to UACR both in the hypertension with early renal damage group(n = 39, r = −0.778, P < 0.05) and the hypertension without early renal damage group(n = 35, r = −0.365, P < 0.05) at the same level of blood pressure,both groups with statistically significant differences.3. It was shown,in multiple linear stepwise analysis of UACR for patients with hypertension,that UACR negatively correlated with urinary renalase but positively with systolic blood pressure, creatinine and heart rate,which was statistically significant. The area of ROC curve of the urinary renalase in hypertension with early renal damage group was 0.894. Conclusion: Urinary renalase progressive decrease may indicate early kidney damage in primary hypertension.