A11140 Association of polymorphism of SFTPA Gene and serum SP-A levels with the risk of severe obstructive sleep apnea in Chinese population

Abstract

Objectives: To investigate the associations of human SFTPA gene polymorphism and serum surfactant proteins A (SP-A) levels with severe obstructive sleep apnea (OSA). Methods: This is a case-control study. 169 subjects with severe OSA and 176 subjects with non-OSA by full night polysomnography were selected as the control and case group. All severe OSA patients and controls were genotyped for four single nucleotide polymorphisms (SNPs) (rs1136451, rs1059225, rs1965708 and rs1059046) of SFTPA gene by Kompetitive Allele Specifc PCR. Serum surfactant proteins A levels were measured by ELISA. Results: The prevalence of severe OSA patients was significantly different between lower serum SP-A levels group and higher serum SP-A levels group (P = 0.015). The lower serum SP-A levels is considered as risk factor for severe OSA after adjustment for covariates (OR: 2.226, 95% confidence interval [CI]: 1.248–3.971, P = 0.007). Moreover, we found that the distribution of additive models (CC 22.2% vs 23.3%, CA 61.1% vs 46.1%, AA 16.7% vs 30.6%, P = 0.039) and recessive models (AA 16.7% vs 30.6%, CA+CC 83.3% vs 69.4%, P = 0.02) of rs1059046 showed significant difference between the higher serum SP-A levels group and lower serum SP-A levels group. The significant difference of the recessive models (AA vs CA+CC) was retained after adjustment for covariates (OR: 2.132, 95% CI: 1.074–4.231, P = 0.03). Conclusion: AA genotype of rs1059046 may be linked with severe OSA by contribute to serum SP-A levels.