A10827 Assessment of left ventricular structure and functional abnormality and association with cardiovascular risks in an Older Community-Dwelling Chinese Population

Abstract

Objectives: To make the clinical determination of abnormal left ventricular structure and function in older Chinese community population. Methods: Shanghai Elderly Cardiovascular Health Study (SHECHS) recruited 3891 elderly residents aged 65 years and over with 593 very elderly age over 80 years. Demographic, laboratory echocardiography and tissue Doppler data were obtained and follow-up 3 years for mortality. Results: We defined a subset of low risk participants free of prevalent cardiovascular disease or risk factors referred to as the ‘low risk reference subgroup’ and use quantile regression to calculate 10th, 50th, and 90th percentile limits with associated 95% confidence limits in the low risk reference subgroup overall and stratified by sex with the resulting 10th and 90th percentile limits considered as reference limits for these measures in the overall SHECHS subjects. Therefore, the reference limit and guideline cutoff value in men and women of LVM, LVM index to BSA, LVEDD, LVEDD index to BSA, LAD, LAD index to BSA, e’, E/e’, EF were determined. And the prevalence of LV hypertrophy, LV enlargement, LA enlargement, abnormal EF and E/e’ were determined according to the SHECHS reference limit. Further multivariate logistic regression analysis shows significance of LAD and E/e’ adjusted by age, sex, BMI, SBP, hemoglobin, fast glucose, LDL-C, homocysteine, UA, creatinine, CK, hsCRP and AF (see Table). Conclusion: Our finding suggested that the use of age-based SHECHS reference limit in Older Community-Dwelling Chinese Population improves the accuracy for identify the subjects with LV structural and functional abnormality. LAD and E/e’ might be more associated with age, sex and cardiovascular risks by multivariate logistic regression analysis, while LV enlargement might be not.