A10642 Effects of masked visceral fat obesity on the blood pressure in patients with diabetes

Abstract

Objectives: Abdominal obesity (AO) is characterized by excessive waist circumference (≥90 cm/85 cm in the male or female) and closely related to elevated blood pressure. This study is aimed to explore the effects of visceral adipose accumulation on the blood pressure in diabetic patients with visceral fat obesity (VFO) but normal waist circumference. Methods: A total of 326 diabetic patients without history of hypertension or antihypertensive drugs were included and abdominal visceral fat area (VA) was assessed by computed tomography. VFO was defined as VA ≥ 100 cm2. All patients were divided into two categories of VFO+ or VFO- group and four subgroups: AO-VFO-, AO-VFO+ (masked VFO), AO+VFO- and AO+VFO+ group. Results: Compared with the VFO- group, systolic and diastolic blood pressure (SBP, DBP) were significantly higher in VFO+ group (P < 0.001). The SBP in masked VFO group (151 ± 18 mmHg) was significantly higher than AO-VFO- (132 ± 16 mmHg, P < 0.001) and AO+VFO-(131 ± 14 mmHg, P < 0.001), but similar to AO+VFO+ group (150 ± 15, P = 0.854). The masked VFO group also has significantly higher DBP (86 ± 13 mmHg) than AO-VFO- (80 ± 11 mmHg, P = 0.007) and AO+VFO-(79 ± 10 mmHg, P < 0.001), but lower than AO+VFO+ group (91 ± 12 mmHg, P = 0.032). Stepwise multiple linear regression analysis showed that abdominal visceral fat area and subcutaneous fat area were the independent risk factors for SBP, while age and visceral fat area were the independent risk factors for DBP. Conclusion: Abdominal visceral adipose accumulation has a marked impact on the blood pressure in diabetic patients, even in those with normal waist circumference.