A10597 Characteristics of Four-limb Blood Pressure in Takayasuʼs Arteritis

Abstract

Objectives: To explore the characteristics of four-limb blood pressure (BP) in Takayasu's arteritis (TA) and confirm the diagnostic value of simultaneously measuring four-limb blood pressure in TA. Methods: We consecutively analyzed 229 inpatients diagnosis with TA from January 2013 to January 2016 in Fuwai Hospital. The data of four-limb blood pressure was collected and compared in 229 TA patients and 150 patients with primary hypertension and 150 normal controls to explore the characteristics of four-limb blood pressure in TA patients. Results: 116 (51%) TA patients suffered from hypertension in the past. Peripheral angiography confirmed that 76 (33%) TA patients had arterial stenosis of upper limbs, in which 28 (12%) TA patients had arterial stenosis of both side upper limbs. 46 (20%), 62 (27%) and 18 (8%) TA patients had arterial stenosis of aorta, renal and low leg respectively. Echocardiography revealed that 53 (23%) TA patients had aortic regurgitation or regurgitation. However, the proportion of absolute inter-arm systolic blood pressure difference (IASBDP) > 10 mmHg, inter-ankle systolic blood pressure difference (IAND) > 10 mmHg, pulse pressure (PP) on the higher arm side of systolic pressure > 60 mmHg, ankle-brachial index (ABI) < 0.9 in TA patients were 54.3%, 20.0%, 48.0%, 27.3% respectively, which was significantly higher than primary hypertensive and healthy people (p < 0.01). There were 189 TA patients (83.3%), 49 primary hypertensive patients (19.3%) and 16 healthy people (10.7%) who met any above-mentioned indicators. Conclusion: Characteristics of four-limb blood pressure in TA patients is distinct. Compared with simple brachial artery blood pressure, simultaneous four-limb blood pressure provide concisely more valuable information which can increase the sensitivity of diagnosis of TA significantly.