A10216 Serum MCP-1 levels are increased in systemic vasculitis of pations with hypertension with renal involvement

Abstract

Objectives: Monocyte chemotactic protein 1 (MCP-1), which is able to adjust the migration of monocytes/macrophages, osmosis and raise monocytes and T lymphocyte cells to participate in a variety of inflammation, are closely linked to various types of systematic vasculitis. However, serum MCP-1 levels have not been evaluated in patients with small and medium vessel vasculitis (SMVV), especially in those with PAN. The study was performed to investigate the level of serum MCP-1 in determining the SMVV. Methods: We reviewed all patients admitted to our center for the etiology screening of hypertension between January 2013 and December 2016. All vasculitis are diagnosed by a rheumatologist and fulfilled the American College of Rheumatology (ACR) 1990 criteria. Serum samples were collected in 43 patients with systemic vasculitis with hypertension and 43 healthy controls (HC). Serums MCP-1 were measured using commercially available ELISA kits. Results: The serum MCP-1 levels were significantly higher in patients with systemic vasculitis, compared with healthy controls (p < 0.001). Furthermore, it was significantly increasing in patients with renal than non-renal involvement (p = 0.001) and HC (p < 0.001). However, there was no significant statistical differences between active and inactive phase. Serum MCP-1 levels with patients in systemic vasculitis were positive correlation with serum creatinine levels (r = 0.387, p < 0.010). Furthermore, there was a closely correlation between 24-hour proteinuria and MCP-1 levels (r = 0.404, p < 0.014). Conclusion: Serums MCP-1 were significantly higher in patients with systemic vasculitis compared with HC, especially in patients with renal involvement. Serum MCP-1 might be as a potential biomarker tools in the systemic vasculitis with renal involvement.